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I think this is a difficult question to answer. The immune system isn't like a muscle, where it really only does one job. You've eliminated the primary defense from your question (skin, cilia, mucus), but the secondary, innate system and the tertiary, adaptive system, all have a large number of roles.

1. Anti- bacteria
2. Anti- fungal
3. Anti-viral
4. Anti- parasitic
5. Anti-cancer

Your immune system's ability do deal with any of those things has a lot of variables (nutrition and genetics to some extent). Your innate system will use different cells for each of those pathogens. Your adaptive response will vary to a large degree as well.

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Here is an article you might find interesting.

There are gases and dust which move up and down in a day-night cycle.

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If nothing else, there's solar wind on the moon.

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I don’t believe there is a high enough density of molecules in the “air” on the moon to produce the same thing we call wind on earth. Sure, they’re going to move around a bit, but they’re unlikely to collide with each other often enough to create a detectable trend of common movement, aka wind.

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The Oort cloud is thought to be spherical because it is believed to be composed of icy objects that were gravitationally drawn together by the Sun's gravity when the solar system was forming. Its spherical shape is also likely due to the fact that it is composed of particles in random orbits, which generally tend to form a spherical shape due to their chaotic orbits.

1. Poor nutrition: Long-term physical inactivity and social isolation can lead to poor nutritional choices, which can lead to chronic health diseases.

2. Lower immunity: Social isolation and physical inactivity can cause a weakened immune system, which can make a person more vulnerable to disease.

3. Hormonal imbalances: A lack of physical activity and social activity can cause hormonal imbalances in the body, which can lead to chronic health conditions.

4. Stress: Prolonged periods of physical inactivity and social isolation can lead to increased stress levels, which can have negative impacts on physical and mental health.

5. Disrupted sleep: Long term physical inactivity and social isolation can lead to changes in the body's circadian rhythms, which can disrupt the body's natural sleep cycle and lead to chronic health issues.

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Maybe. I like to think they have an equivalent to David Attenborough who talks about preserving our world and not intervening on alien space Netflix