I appreciate your knowledge on the subject!

I have a biology PhD but I'm not a cancer specialist by any means. I just try to read the actual science whenever an article like this gets posted to reddit to give a more realistic assessment of the findings.

U got a big boi huh? Congrats 😁

This kid a whole 2 units, like damn

30% for AML seems good.

If you look at the metric of pathologist workflow and number of times we have to present at tumor boards…KMT2a leukemias are often a lotta work. Induction chemo often doesn’t work well. They recur all the time. They can be 20-30% of pediatric ALL that doesn’t respond to CAR-T (cell based therapy seen in the news for dramatic effect and obscene cost). If you could precondition patients with this type of leukemia before CAR-T more might be eligible.

Many of the patients aren’t healthy enough for a haircut either, so any treatment that doesn’t often kill em in the process (marrow transplant) is especially good.

It all depends on the lens with which you see the world

As long as you don't earn money on the abuse, then you will get subsidies to even do it more.

If you didn't require proof of renters insurance (who you can go after in the event a tenant trashes you property, thereby eliminating a judgment-proof tenant), that is your fault. If you could not afford to lower the rent to make your rate of rent competitive when requiring this as a condition, this is again your own fault. If you lacked the resources to afford unforseen expenses related to property ownership and rising interest rates, this is again, your own fault.

Landlords have infinite recourse and ability to mitigate risk. I have been both a renter and property owner, I understand. I could be a landlord, I have the means. I choose not to, because it would be direct participation in an unethical arrangement.

There's nothing to get. Landlord's had enough money to buy ANOTHER house. There's no "woe is me" to be found here. Landlord's chose to make money from someone else paying for the majority of a house that the tenant likely could have afforded to pay for, if artificial, arbitrary barriers to entry were removed.

If you entered into the practice and ended up in a bad financial position as a result of stacking bad investment decisions, it's regrettable you're in that position, but it's entirely of your own making. You chose to engage in a practice that had risk to extract someone else's income as your own wealth.

Nobody holds a gun to a landlord's head to force them into it. You could have taken the thousands upon thousands of dollars and invested them elsewhere, preferably not a practice that makes the real estate market a tiny bit worse for everyone you're ahead of.

But, this is where Trump wants to build his city with flying cars.

Thanks. It says in the article 30% of AML for NPM1, I misread it. Also 5-15% of "acute leukemias" for KMT2A rearrangements.

Obligatory - fuck cancer! Hope they'll find cure for all of them and we'll read about it only in textbooks like we read about tuberculosis.

that is very rare. most zoos are not like that.

Pedantic: KMT2A-R (lysine’s amino acid abbreviation is K, MethylTransferase 2A - Rearranged). For the hematologists and oncologists from a while ago, KMT2a used to be called MLL. Nasty disease.

KMT2a is about 4-5% of acute myeloid leukemia in adults, maybe 20% in kids (but kid AML is rare, their leukemia is mostly ALL, although KMT2a can also be rearranged in ALL, because MLL stood for “mixed lineage leukemia” cause it couldn’t seem to make up its mind which type it was). Sorta don’t think it shakes out to an actual 10%, but if you look at the cases where people do badly it’s enriched.

NPM1 is a common form of AML, 30% seems about right…just for AML. But when you factor in CLL, CML, and other forms of leukemia, it’s not 30% of all leukemias.

TL;DR: this works in a disease where not much works. Percentages are hard when the denominator isn’t made clear, and this is especially true here because there are a lot of leukemia subtypes.

Yeah shitty reporting has basically destroyed science especially now that nobody reads beyond a headline. Scientists are the unsung heroes of the modern world.

Are you talking about his land he sold in 2006?

Wow, this is amazing. I fucking hate cancer, it has taken so many loved ones away. This is a huge step in the right direction.

It's always that way.

As a scientist, we work extremely hard only to be undermined by reporters who cause the public to lose faith in scientists.

Scientist: Our clinical trial for a new therapy saw 18 of 60 patients get complete remission. We would have expected about 6 of 60, so this is an improvement.

Clickbait article: New therapy sees cancer VANISH in 18 patients.

Scientist: 😥

Public: OMG HOW MANY TIMES HAVE WE HEARD "SCIENTIST CURES CANCER" ITS ALL LIES AND BULLSHIT

Scientist: 😞

It doesn't seem like that - the numbers still seem really good if YOU had that one special type of cancer, it would mean that you had a significantly better chance with this treatment.

I don't think that a cancer cure will come in the form of one treatment for ALL (which would be very nice), but it's going to be attacking specific forms and variations.

30% of them

You’ll never get it. Save your cash and find a fixer upper. You work your butt off and have someone destroy it. But it’s ok because… screw those people right? Insurance doesn’t cover anywhere near what you assume it does.

I thought I put 'almost always' ... always is almost always a bad idea to use absolutely. Updating. Thank you!!

I suspect someone found a dog out in the middle of nowhere, figured he had been abandoned by an owner who thought he was old, so they saved him. Seven years later, he wandered off again.

With that cancer out of the way it should be much easier to treat their leukaemia.

So cool!

He probably accounts for all the “Bigfoot prints”found throughout Michigan. 🤣

Basically a clickbait article. It’s a nice thing to have developed but no cure.