What was the best part of this movie for you?

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Hi all, thanks for doing this. Liquid biopsies seem to be very effective at determining probability of recurrence when samples can be referenced to observed tumor mutations. How does this work with no patient matched tumor genome?

Also, the prevalence of ovarian cancer is relatively low among the general population, which I imagine makes the test more difficult. A test of high sensitivity (>95%) would still lead to many false positives. Is this a concern?

Thanks for doing this! What is the newest/best way to screen for colon cancer?

>What part of your research excites you all the most?

Thank you for your question. We are currently optimising the design of the microfluidic device to efficiently isolate exosomes from an ovarian cancer cell line. So still at its very early stages. The key challenge is to capture cancer cell-derived exosomes (the biomarkers we are interested in) from the total population of exosomes (healthy cell-derived + cancer cell-derived). This is because the latter are a very small fraction of the total population and also because of their size (a few nanometres) it is harder to capture and detect them with existing technology. Overall, this is a really exciting project, and when realised, would pave way for a national level screening programme for early detection of ovarian cancer. The parts that we are most excited about are(i) identifying reliable biomarkers for early stages of ovarian cancer and (ii) being able to effectively capture and detect them within our device.

Thanks for the question 😊 the vortex mixers do have multiple uses. We are using a few approaches to develop the devices; photolithography is one of them as you say, but we are also using higher resolution 3D printers to produce cheaper at scale microfluidic devices.

What stage of research are you in regarding the device for detecting ovarian cancer? What part of your research excites you all the most?

Hi guys, Do you have a tabletop vortex mixer, and if so how often do you stick your finger into it? (in my opinion its the best part of being in science)

less importantly, are your microfluidic devices silicon based (using the same processing as silicon fabrication, such as photolithography), or can you make MF devices with plastics? as I assume the latter would be cheaper.

Exactly :) we would be able to use smaller amounts

>idic devices. Some vaccines are manufactured through high-throughput microfluidics. Microfluidics can give us the ability to have lab-on-chips, where we miniaturise all the components, we can carry out in a lab onto one chip.

Wow! So you wouldn't need a large amount of blood to detect cancer?

Sure, thanks your question, microfluidics enables us to do lots of different things with tiny volumes/amounts of fluids which are applied to lots of different fields from bioengineering to catalysis. By having micro-sized channels, we can incorporate them into devices to enable us to work on much smaller scales. This helps us investigate fundamental questions such as how a fluid flows at the microscale (around the thickness of a single human hair) but also enables high-throughput screening and manufacturing through multiplexing (putting lots of devices together) microfluidic devices. Some vaccines are manufactured through high-throughput microfluidics. Microfluidics can give us the ability to have lab-on-chips, where we miniaturise all the components, we can carry out in a lab onto one chip.

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Hi team. Can you tell me a little more about what microfluidics is please?

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Hi everyone. Sorry we're late, we were having some technical difficulties.

No, i mean like adding lemon peel etc to it in game

No expectations, though we're doing what we can to make it solid and known within its genre.

The setting is not that precisely mirrored in one place so we could specify a County. During our research, we decided will focus on Appalachia. You get to build your bases in the mountains, forest, swamp, then a small and big city. It's definitely the USA, so you could think of it as Franklin County too, I guess... ;-)

Do you mean if we can taste or smell the moonshine? That's reserved for the real experience. Impossible even in VR games ;-)

Wow, now that's a crazy thing to do when drunk! Haha!
The game might give you an idea about the process, yes ;-) It's cheaper than a physical set and you'd learn interesting things quickly through having fun. Might encourage you to finally use your set! :D
Then, you also can get in touch with our growing community on Discord: https://discord.gg/WMKV9kztNV

We used Unity, which is an industry-standard and we would probably go for it again if developing a sequel.

You will need to install either the Steam app or GOG to be able to purchase and play the game. Here is an example tutorial on how to install Steam: https://www.youtube.com/watch?v=XKpbJ9NygvE
Then you have to create your account, add a payment method and then you're ready to browse and buy the game on Steam. Then you will have to go to your library, add a game and activate the key you purchased. Sounds complicated, but it's not that hard! :D

Yes! Please join our Discord channel to stay updated: https://discord.gg/WMKV9kztNV! Yesterday we released a patch that should fix this issue. We apologize you experienced this bug.