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Runyc2000 t1_jegcxgc wrote

That has happened to me. I studied but couldn’t quite understand the topic. I went in for the test and read the questions. They were phrased in such a way that it made everything click in to place so to speak and I understood things better.

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crna2023 t1_jegcvo1 wrote

They have a ceiling effect that is theorized to occur because of how they work on the GABA receptor (the receptor that is responsible for its mechanism of action). They are thought to work similarly to many other anesthetics such as propofol however their effect has a dose ceiling. I disagree that it is hard to die from OD, if you have the right comorbidities or are using them along with other drugs such as alcohol it is very easy to OD.

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ShowerGrapes t1_jegcv9f wrote

written language came about long after cities and industry and all that. it was the development of agriculture, that freed up time to create more interesting things (initially with clay) and then the wheel (to carry more stuff around) that led to the need to keep track of the massive hoards that local warlords (i.e. 'heroes') were collecting from the subjugated masses. our first written documents were lists of things kept in treasuries and trade lists between cultures.

so you have it backward but the point might still be valid.

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